p63 is a tumor-suppresor gene from the p53
family involved in epithelial stem cell maintenance of the skin and mammary
glands. The p63 protein has two main isoforms with varied functions, one
lacks (ΔNp63) and the other
retains the transactivation domain (TAp63).
ΔNp63 is commonly studied, but TAp63 has been shown to be
crucial for skin cell maintenance and is implicated in breast cancer. Recent
research suggests TAp63 suppresses tumor progression by regulating microRNA
biogenesis and interacting with integrins and growth factors. The Hippo
pathway also influences breast cancer and interacts with p63 isoforms,
affecting cell polarity and stem cell properties. Understanding these
interactions is vital for diagnosing and treating breast cancer effectively.
This antibody recognizes both TAp63 and ΔNp63. The target epitope PSHLIR is located within amino acids 261-266 of TAp63, and 167-172 of ΔNp63.
References:
Su X, et al. Oncogene. 2017;36(17):2377-2393.
Nekulova,
Marta et al. Virchows Archiv : an international journal of pathology vol. 463,3
(2013): 415-25.
Product Overview
Key info about the protein can be found under Product Information > Specifications and Features.
Alternative names: tumor protein p63, TAp63 + deltaNp63
