PP002Hu-Ac has been Customer-Verified in high stringency biophysical assays
Eukaryotic translation initiation factor 4E or
eIF4E is part of the eukaryotic translation initiation complex eIF4F. eIF4E plays
a key role in regulating translation initiation through its recognition and
binding of the 7-methylguanosine (m7GTP) cap found at the 5’ end of
mRNA1. This allows the recruitment of ribosomes to the 5’ cap
structure2. In cancer, increased levels of eIF4E are correlated with
poor prognosis3,4. eIF4E is regulated at the RNA and protein level. This is achieved through changes in gene expression, RNA stability, protein phosphorylation, subcellular localization and through interactions with binding proteins such as 4E-BPs5.
The active version of this product (PP002Hu-Ac) is suitable for binding studies6.
References:
1. Gingras AC, Raught B & Sonenberg N, 1999, Annu. Rev. Biochem. 68:913–963
2. Rhoads RE, 1988, Trends Biochem Sci. 13:52-6
3. Montanaro L, Pandolfi PP, 2004, Cell Cycle. 3:1387-9
4. Urtishak, KA et al., 2019, Oncogene. 38 (13):2241-2262
5. Richter JD; Sonenberg N, 2005, Nature. 433 (7025):477–480
6. Frosi, Y et al. 2022, RSC Chem. Biol. 3 (7):916-930
Product Overview
Key info about the protein can be found under Product Information > Specifications and Features.
This eIF4E recombinant protein comes in two forms: active and inactive.
Alternative names = wild type eIF4E, CBP, EIF4F, eIF4E, AUTS19, EIF 4F, EIF4E1, eIF 4E, eIF-4E, EIF4EL1, MGC111573, IF4E_HUMAN, eIF 4F 25 kDa subunit, mRNA cap binding protein, Messenger RNA Cap Binding Protein eIF 4E, Eukaryotic translation initiation factor 4 E, Eukaryotic translation initiation factor 4E like 1
