Anti-TAp63 antibody (TAp63-4.1, BSA-Free)

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    p63 is a tumor-suppresor gene from the p53 family involved in epithelial stem cell maintenance of the skin and mammary glands. The p63 protein has two main isoforms with varied functions, one lacks (ΔNp63) and the other retains the transactivation domain (TAp63).

    ΔNp63 is commonly studied, but TAp63 has been shown to be crucial for skin cell maintenance and is implicated in breast cancer. Recent research suggests TAp63 suppresses tumor progression by regulating microRNA biogenesis and interacting with integrins and growth factors. The Hippo pathway also influences breast cancer and interacts with p63 isoforms, affecting cell polarity and stem cell properties. Understanding these interactions is vital for diagnosing and treating breast cancer effectively.

    This antibody recognises the target epitope LSDPxW motif which is located within the C-terminal region of TAp63. This sequence is absent in ΔNp63 and the p63 paralog p73, thus this antibody is not predicted to react with either protein.

    References: Su X, Napoli M, Abbas HA, et al. Oncogene. 2017;36(17):2377-2393.

    Product Overview

    Key info about the protein can be found under Product Information > Specifications and Features.

    Alternative names: transactivation domain of tumor protein p63, Transactivation Tumor protein 63