p63 is a tumor-suppresor gene from the p53 family
involved in epithelial stem cell maintenance of the skin and mammary
glands. The p63 protein has two main isoforms with varied functions, one
lacks (ΔNp63)
and the other retains the transactivation domain (TAp63).
ΔNp63 is commonly
studied, but TAp63 has been shown to be crucial for skin cell maintenance
and is implicated in breast cancer. Recent research suggests TAp63 suppresses
tumor progression by regulating microRNA biogenesis and interacting with integrins
and growth factors. The Hippo pathway also influences breast cancer and
interacts with p63 isoforms, affecting cell polarity and stem cell properties.
Understanding these interactions is vital for diagnosing and treating breast
cancer effectively.
This antibody recognises the target epitope LSDPxW motif which is located within the C-terminal region of TAp63. This sequence is absent in ΔNp63 and the p63 paralog p73, thus this antibody is not predicted to react with either protein.
References: Su X, Napoli M, Abbas HA, et al. Oncogene. 2017;36(17):2377-2393.
Product Overview
Key info about the protein can be found under Product Information > Specifications and Features.
Alternative names: transactivation domain of tumor protein p63, Transactivation Tumor protein 63
